Structural highlights
3eum is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , |
| Related: | 1l1h, 1jpq, 1jrn, 3ce5, 3em2, 3eqw, 3eru, 3es0, 3et8, 3eui |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Publication Abstract from PubMed
A series of disubstituted acridine ligands have been cocrystallized with a bimolecular DNA G-quadruplex. The ligands have a range of cyclic amino end groups of varying size. The crystal structures show that the diagonal loop in this quadruplex results in a large cavity for these groups, in contrast to the steric constraints imposed by propeller loops in human telomeric quadruplexes. We conclude that the nature of the loop has a significant influence on ligand selectivity for particular quadruplex folds.
Selectivity in Ligand Recognition of G-Quadruplex Loops (dagger).,Campbell NH, Patel M, Tofa AB, Ghosh R, Parkinson GN, Neidle S Biochemistry. 2009 Feb 4. PMID:19173611[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Campbell NH, Patel M, Tofa AB, Ghosh R, Parkinson GN, Neidle S. Selectivity in Ligand Recognition of G-Quadruplex Loops (dagger). Biochemistry. 2009 Feb 4. PMID:19173611 doi:10.1021/bi802233v
