Talin

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Talin is involved in cell-cell contacts. It links integrins to actin. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F0-F3. The F3 subdomains interacts with integrin. Talin contains 3 Vinculin binding sites VBS1-VBS3.