1os2

From Proteopedia

proteopedia linkproteopedia link

spinqualitylabelsall models PDB ID 1os2 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
, resolution 2.15Å
Ligands:	, , , and
Gene:	MMP12 OR HME (Homo sapiens)
Activity:	Macrophage elastase, with EC number 3.4.24.65
Coordinates:	save as pdb, mmCIF, xml

Ternary enzyme-product-inhibitor complexes of human MMP12

Disease

Known diseases associated with this structure: Cardiomyopathy, dilated, 1G OMIM:[188840], Cardiomyopathy, familial hypertrophic OMIM:[188840], Muscular dystrophy, limb-girdle, type 2J OMIM:[188840], Myopathy, early-onset, with fatal cardiomyopathy OMIM:[188840], Myopathy, proximal, with early respiratory muscle involvement OMIM:[188840], Tibial muscular dystrophy, tardive OMIM:[188840]

About this Structure

1OS2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

X-ray structures of binary and ternary enzyme-product-inhibitor complexes of matrix metalloproteinases., Bertini I, Calderone V, Fragai M, Luchinat C, Mangani S, Terni B, Angew Chem Int Ed Engl. 2003 Jun 16;42(23):2673-6. PMID:12813751

Page seeded by OCA on Thu Mar 20 13:14:53 2008