Thymidylate kinase
From Proteopedia
Thymidylate kinase (TMK) catalyzes the conversion of thymidine-5’-phosphate (dTMP) and ATP to thymidine-5’-diphosphate and ADP. TMK is important for DNA synthesis. Inhibitors of TMK include bisubstrate compounds of the type TP(n)X where P(n) are the number of phosphoryl groups and X is the nucleoside moiety of the acceptor. The TMK inhibitor azido-dTMP (AZTP) is an HIV AZT prodrug metabolite. For more details see Student Project 8 for UMass Chemistry 423 Spring 2015.
3D Structures of thymidylate kinase
Updated on 22-February-2016
