Tubulin tyrosine ligase

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spinqualitylabelsall models Tubulin tyrosine ligase complex with ADP and Mg+2 ions (PDB code 3tin) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Tubulin tyrosine ligase (TTL) adds tyrosine in an ATP-dependent reaction to the C-terminal of a detyrosinated a-tubulin. The detyrosination of a-tubulin is a posttranslational modification which exposes glutamate in the new tubulin C-terminal. The detyrosinated a-tubulin forms Glu-microtubules. Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function Disease Mutated TTL causes morphogenic abnormalities and cancer. Relevance Structural highlights

3D Structures of tubulin tyrosine ligase

Updated on 20-July-2015

3tig – fTTL - frog
3tii – fTTL + phosphomethylphosphonic acid adenylate
3tin – fTTL + ADP
4iij – cTTL + rSTM + tubulin + GTP + GDP - chicken
4ihj – cTTL + rSTM + tubulin + GTP + GDP + ADP
4wbn – cTTL + rSTM + tubulin + GTP + GDP + phosphomethylphosphonic acid adenylate
4o2a – cTTL + rSTM + tubulin + GTP + GDP + ADP + inhibitor
4i4t – cTTL + rSTM + tubulin + GTP + GDP + zampanolide
4i50 – cTTL + rSTM + tubulin + GTP + GDP + epothilone
4o4l, 4tuy, 4tv8, 4yj2, 4yj3 – cTTL + rSTM + tubulin + GTP + GDP + anti-cancer drugs
4i55 – cTTL + rSTM + tubulin + GTP + GDP + phosphomethylphosphonic acid adenylate
4o2b – cTTL + rSTM + tubulin + GTP + GDP + phosphomethylphosphonic acid adenylate + anti-gout drug
4o4h, 4o4j, 4o4i – cTTL + rSTM + tubulin + GTP + GDP + phosphomethylphosphonic acid adenylate + anti-cancer drug

References