UDP-galactose 4-epimerase

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spinqualitylabelsall models Structure of UDP-galactose 4 epimerase complex with NAD, UDP (stick model), PEG and Na+1 (purple) ions (PDB entry 1nah) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function UDP-galactose 4-epimerase (GalE) reversibly converts UDP-galactose to UDP-glucose. GalE catalyzes the last step in galactose metabolism[1]. GalE uses NAD+ as a cofactor. Disease Mutations in GalE are the cause of galactosemia which is autosomal recessive disorder[2].

3D structures of UDP-galactose 4 epimerase

Updated on 05-December-2016

References

1. ↑ Mozzi F, Savoy de Giori G, Font de Valdez G. UDP-galactose 4-epimerase: a key enzyme in exopolysaccharide formation by Lactobacillus casei CRL 87 in controlled pH batch cultures. J Appl Microbiol. 2003;94(2):175-83. PMID:12534808
2. ↑ Park HD, Park KU, Kim JQ, Shin CH, Yang SW, Lee DH, Song YH, Song J. The molecular basis of UDP-galactose-4-epimerase (GALE) deficiency galactosemia in Korean patients. Genet Med. 2005 Nov-Dec;7(9):646-9. PMID:16301867 doi:10.109701.gim.0000194023.27802.2d