Structural highlights
4elt is a 3 chain structure with sequence from Thermus aquaticus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , , , |
| NonStd Res: | |
| Related: | 3ojs, 3oju, 4elu, 4elv |
| Gene: | polA, pol1 (Thermus aquaticus) |
| Activity: | DNA-directed DNA polymerase, with EC number 2.7.7.7 |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Publication Abstract from PubMed
Modified nucleotides play a paramount role in many cutting-edge biomolecular techniques. The present structural study highlights the plasticity and flexibility of the active site of a DNA polymerase while incorporating non-polar "Click-able" nucleotide analogs and emphasizes new insights into rational design guidelines for modified nucleotides.
Interactions of non-polar and "Click-able" nucleotides in the confines of a DNA polymerase active site.,Obeid S, Busskamp H, Welte W, Diederichs K, Marx A Chem Commun (Camb). 2012 Aug 28;48(67):8320-2. Epub 2012 Jul 6. PMID:22766607[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Obeid S, Busskamp H, Welte W, Diederichs K, Marx A. Interactions of non-polar and "Click-able" nucleotides in the confines of a DNA polymerase active site. Chem Commun (Camb). 2012 Aug 28;48(67):8320-2. Epub 2012 Jul 6. PMID:22766607 doi:http://dx.doi.org/10.1039/c2cc34181f
