From Proteopedia
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Summary of the most extensively characterized CRISPR endoribonucleases[1][2]
Representatives of class 1 and class 2
Class 1 CRISPR-Cas systems are considered to be the evolutionary ancestral systems. The class 2 systems have evolved from class 1 systems via the insertion of transposable elements encoding various nucleases, and are now being used as tools for genome editing.[2]
(4qyz).
(3x1l).
(5f9r).
5b43.
Class 1
CRISPR subtype III-B (Cmr complex)
CRISPR subtype Orphan
- TthCas6A (TTHB78) from T. thermophilus. (4c8z). Other representatives: 4c8y, 4c97.
CRISPR type IV (Csf1)
Class 2
CRISPR type VI (C2c2)
See aslo
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References
- ↑ Hochstrasser ML, Doudna JA. Cutting it close: CRISPR-associated endoribonuclease structure and function. Trends Biochem Sci. 2015 Jan;40(1):58-66. doi: 10.1016/j.tibs.2014.10.007. Epub, 2014 Nov 18. PMID:25468820 doi:http://dx.doi.org/10.1016/j.tibs.2014.10.007
- ↑ 2.0 2.1 Mohanraju P, Makarova KS, Zetsche B, Zhang F, Koonin EV, van der Oost J. Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems. Science. 2016 Aug 5;353(6299):aad5147. doi: 10.1126/science.aad5147. PMID:27493190 doi:http://dx.doi.org/10.1126/science.aad5147
