Structural highlights
4m4n is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , |
| Related: | 2xcy, 2xzi, 2xzj, 2xzk, 4m4u, 4m4v |
| Activity: | Exo-alpha-sialidase, with EC number 3.2.1.18 |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Function
[SIA_ASPFU] Sialidase is able to release sialic acid from a wide variety of natural substrates including bovine salivary mucin, colominic acid, bovine fetuin, a serum glycoprotein containing both alpha-2-6 and alpha-2-3-linkages in a ratio of about 3:2, and glycoproteins and glycolipids from thermally denatured human lung epithelial cells. Does not show any trans-sialidase activity since it is able to remove terminal sialic acid residues but is unable to catalyze their transfer to the acceptor substrate. 2-keto-3-deoxynononic acid (KDN) is the preferred substrate and A.fumigatus can utilize KDN as a sole carbon source.[1]
References
- ↑ Warwas ML, Yeung JH, Indurugalla D, Mooers AO, Bennet AJ, Moore MM. Cloning and characterization of a sialidase from the filamentous fungus, Aspergillus fumigatus. Glycoconj J. 2010 Jul;27(5):533-48. doi: 10.1007/s10719-010-9299-9. Epub 2010 Jul, 23. PMID:20652740 doi:http://dx.doi.org/10.1007/s10719-010-9299-9
