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Function
Structure
The apo form of Gemin5 shows 14 WD motifs able to fold into 2 connected seven-bladed β-propellers. The first doughnut-shaped propeller is called WD1 and is composed of blades 1 to 7 corresponding to the amino acids 19 to 377. The second is called WD2, composed of blades 8 to 14 corresponding to the amino acids 428 to 712. They are very similar in size, with around 38 Å in diameter, around 55 Å high and twisted around 15° askew relative to one another. The N-terminal region of WD1 forms the outermost β-strand of blade 14 in WD2. This structural motif is said to be referred to a “molecular velcro”, also found in the structure of Aip1.
The WD-40 motif is also known as WD or beta-transducin. It is a short motif which contains around 40 amino acids and often ended with the Trp-Asp, or W-D, amino acids. Most of the time, WD-40 motifs folded into a 7-8 bladed beta-propeller. Proteins containing WD motifs exist in all eukaryotes and have different functions. Repeated WD-40 motifs are a site for protein-protein interactions and it had been shown that they act as platforms for the assembly of protein complexes. The specificity of the recognition is based on the sequences outside the repeats. Here are some examples of proteins which contains such a motif : E3 ubiquitin ligase [(PUBMED:11814058), (PUBMED:10322433)], TAFII transcription factor, beta subunit of G proteins.
Disease
Relevance
Structural highlights
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