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You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
Function
Guanine nucleotide exchange factor (GEF) of the Rho/Rac GTPases [3], including Ras and Cdc42.
Disease
Relevance
Structural highlights
The Vav1 are (from N ter to C ter): a calponin-homology (CH) domain, an acidic (Ac) domain, a DBL-homology (DH) domain also known as a rhoGEF domain, a pleckstrin-homology (PH) domain, a phorbol esters/diacylglycerol binding (C1) domain and Src-homology (SH) 3 and 2 domains. [4]
: When the CH domain is deleted, Vav has a phosphorylation-independant GEF activity. The conclusion is that the CH domain intervenes in the auto-inhibition of Vav. Studies on Vav3 implies that this is due to interactions from the CH domain with the Ac, DH and C1 regions.[5]
