Function
Adenylosuccinate lyase (ADSL) is a bifunctional enzyme acting in purine synthesis and purine nucleotide recycling[1]. ADSL caalyzes two reactions: the cleavage of adenylsuccinate to AMP and fumarate and the cleavage of phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) into 5-aminoimidazole-4-carboxamide (AICAR) and fumarate.
Disease
Mutations in ADSL cause autosomal recessive disorder which manifests itself by encephalopathy with epilepsy and marked psychomotor retardation[2].
Structural highlights
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
