1t5w
From Proteopedia
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| , resolution 2.40Å | |||||||
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| Gene: | HLA-DRA (Homo sapiens), HLA-DRB1 (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HLA-DR1 in complex with a synthetic peptide (AAYSDQATPLLLSPR)
Overview
Peptides bind to class II major histocompatibility complex (MHC) proteins in an extended conformation. Pockets in the peptide binding site spaced to accommodate peptide side chains at the P1, P4, P6, and P9 positions have been previously characterized and help to explain the obtained peptide binding specificity. However, two peptides differing only at P10 have significantly different binding affinities for HLA-DR1. The structure of HLA-DR1 in complex with the tighter binding peptide shows that the peptide binds in the usual polyproline type II conformation, but with the P10 residue accommodated in a shallow pocket at the end of the binding groove. HLA-DR1 variants with polymorphic residues at these positions were produced and found to exhibit different side chain specificity at the P10 position. These results define a new specificity position in HLA-DR proteins.
About this Structure
1T5W is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
A polymorphic pocket at the P10 position contributes to peptide binding specificity in class II MHC proteins., Zavala-Ruiz Z, Strug I, Anderson MW, Gorski J, Stern LJ, Chem Biol. 2004 Oct;11(10):1395-402. PMID:15489166
Page seeded by OCA on Thu Mar 20 14:14:15 2008
