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Biological Function
Caspase-6 is a protease involved in apoptosis. It is most notably involved in neurodegenerative diseases, such as Alzheimer's disease and dementia.
Structural Overview
Inactive State
When the protein is in the inactive state it is a Homotetramer.
Active State
Caspase-6 enters the active state by self-cleaving at residue 193 after a sequence of TEVD. The protein then becomes a Tetramer of Dimers.
Mechanism of Action
Mechanism is unknown as of right now. The active sight is known to be HIS-121, CYS-163, and GLU-174.
Zinc Ligand(s)
Other Ligands
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