Function
Trypanothione reductase (TTR) is a flavoenzyme which catalyzes the reaction converting trypanothione (TPT) and NADP to trypanothione disulfide and NADPH. TTR uses FAD as cofactor.
Relevance
TTR is found only in parasitic protozoa, hence its inhibitors are used as effective drugs against diseases like Chagas Disease caused by the parasites Trypanosoma and Leishmania[1].
Structural highlights
The active site of TTR contains two catalytic cysteine residues which are part of the electron transfer function of the enzyme and the bound TPT substrate[2].
