Caspase-6 is classified as an endopeptidase[1] involved in apoptosis. In terms of its catalytic function, it is a part of the cysteine-aspartate family [2]. It's primarily involved in apoptosis through a largely ambiguous mechanism. Before Caspase-6 is a functional and active dimer, the enzyme exists as a , also known as zymogen [3]. Zymogen activation is largely conserved across the caspase family, however, Caspase-6 is unique in that it becomes active through self-cleavage rather than cleavage by a separate enzyme.The unprocessed enzyme contains a and subunit, a , as well as an intersubunit linker.
