PMID:17986575</ref> .
Disease
Relevance
Ets1 promotes invasive behavior in endothelial cells, smooth muscle cells and epithelial cancer cells.
Structural highlights
Ets1 contains an ETS domain (residues 332-415) which is a helix-turn-helix DNA-binding domain which recognizes the sequence GGAA/T. The ETS domain is flanked by autoinhibitory domains. At the N-terminal, Ets1 contains a pointed domain (PNT) (residues 54-135) and a MAP kinase phosphorylation domain. PNT domain is related to SAM domains and contains 4 α-helices.
(PDB code 1mdm).[1]
