Gp41

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 1aik

Contents 1 Function 2 Relevance 3 3D Structures of Gp41 4 References

Function

Gp41 is a subunit of the envelope protein of retrovirus^[1]. Gp41 is a transmembrane protein and contains several sites which are involved in the infection of the host cells. Gp160 is the cleavable precursor of Gp41 and Gp120. For more details see Hiv env proteins.

Relevance

Fusion inhibitory drugs which bind to Gp41 prevent the attachment of the HIV-1 virus to the cell^[2].

3D Structures of Gp41

Updated on 16-March-2016

References

1. ↑ Chan DC, Kim PS. HIV entry and its inhibition. Cell. 1998 May 29;93(5):681-4. PMID:9630213
2. ↑ Root MJ, Steger HK. HIV-1 gp41 as a target for viral entry inhibition. Curr Pharm Des. 2004;10(15):1805-25. PMID:15180542