Structural highlights
Publication Abstract from PubMed
We have determined single crystal structures of an A-DNA decamer and a B-DNA dodecamer at 0.83 and 0.95 A, respectively. The resolution of the former is the highest reported thus far for any right-handed nucleic acid duplex and the quality of the diffraction data allowed determination of the structure with direct methods. The structures reveal unprecedented details of DNA fine structure and hydration; in particular, we have reexamined the overall hydration of A- and B-form DNA, the distribution of water around phosphate groups, and features of the water structure that may underlie the B to A transition.
X-ray crystallographic analysis of the hydration of A- and B-form DNA at atomic resolution.,Egli M, Tereshko V, Teplova M, Minasov G, Joachimiak A, Sanishvili R, Weeks CM, Miller R, Maier MA, An H, Dan Cook P, Manoharan M Biopolymers. 1998;48(4):234-52. PMID:10699842[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Egli M, Tereshko V, Teplova M, Minasov G, Joachimiak A, Sanishvili R, Weeks CM, Miller R, Maier MA, An H, Dan Cook P, Manoharan M. X-ray crystallographic analysis of the hydration of A- and B-form DNA at atomic resolution. Biopolymers. 1998;48(4):234-52. PMID:10699842 doi:<234::AID-BIP4>3.0.CO;2-H http://dx.doi.org/10.1002/(SICI)1097-0282(1998)48:4<234::AID-BIP4>3.0.CO;2-H
