Ribosomal protein L3

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Template:STRUCTURE 2xg0

Contents 1 Function 2 Relevance 3 3D Structures of Ribosomal protein L3 4 References

Function

Ribosomal protein L3 (RPL3 ) is one of the 34 proteins which belong to the of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It binds to 23S RRNA near the 3'-end where it nucleates the assembly of the large subunit^[1]. In the archaea like in Haloarcula marismortui the L3 is called L3P (RPL3P).

Relevance

Mutations in RPL3 are associated with reduced susceptibility to the antibiotic tiamulin^[2].

3D Structures of Ribosomal protein L3

Updated on 14-August-2016

2ogm, 2ogn, 2ogo – RPL3 + 23S RRNA + antibiotic – Deinococcus radiodurans

References

1. ↑ Petrov A, Meskauskas A, Dinman JD. Ribosomal protein L3: influence on ribosome structure and function. RNA Biol. 2004 May;1(1):59-65. Epub 2004 May 1. PMID:17194937
2. ↑ Pringle M, Poehlsgaard J, Vester B, Long KS. Mutations in ribosomal protein L3 and 23S ribosomal RNA at the peptidyl transferase centre are associated with reduced susceptibility to tiamulin in Brachyspira spp. isolates. Mol Microbiol. 2004 Dec;54(5):1295-306. PMID:15554969 doi:http://dx.doi.org/10.1111/j.1365-2958.2004.04373.x