Ribosomal protein S7

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Contents 1 Function 2 Disease 3 3D Structures of Ribosomal protein S7 4 References

Function

Ribosomal protein S7 (RPS7) is one of the 22 proteins which belong to the 30S of the bacterial ribosome or the 30 proteins which belong to the 40S small subunit of the eukaryotic ribosome. It binds to 16S RRNA and is one of the proteins responsible for the initiation of the 30S particle assembly. It crosslinks with tRNA at the A- and P-sites^[1].

Disease

Mutations in mitochondrial RPS7 cause congenital sensorineural deafness and progressive hepatic and renal failure^[2].

3D Structures of Ribosomal protein S7

Updated on 16-August-2016

References

1. ↑ Dean D, Yates JL, Nomura M. Identification of ribosomal protein S7 as a repressor of translation within the str operon of E. coli. Cell. 1981 May;24(2):413-9. PMID:7016341
2. ↑ Menezes MJ, Guo Y, Zhang J, Riley LG, Cooper ST, Thorburn DR, Li J, Dong D, Li Z, Glessner J, Davis RL, Sue CM, Alexander SI, Arbuckle S, Kirwan P, Keating BJ, Xu X, Hakonarson H, Christodoulou J. Mutation in mitochondrial ribosomal protein S7 (MRPS7) causes congenital sensorineural deafness, progressive hepatic and renal failure and lactic acidemia. Hum Mol Genet. 2015 Apr 15;24(8):2297-307. doi: 10.1093/hmg/ddu747. Epub 2015 Jan, 2. PMID:25556185 doi:http://dx.doi.org/10.1093/hmg/ddu747