Sarcosine oxidase

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Template:STRUCTURE 3ad8 Sarcosine oxidase (SOX) catalyzes the demethylation of sarcosine+O2+H4-tetrahydrofolate to produce glycine, hydrogen peroxide and 5, 10-methylene-tetrahydrofolate. Sarcosine metabolism can be the source of carbon and energy for many microorganisms. SOXs are found as monomers, heterodirmers and heterotetramers[1]. Monomeric SOX uses FAD as cofactor. Heterotetrameric SOX uses FAD and FMN as cofactors.

3D structures of sarcosine oxidase

Updated on 23-August-2016

References

  1. ↑ Suzuki H. Sarcosine oxidase: structure, function, and the application to creatinine determination. Amino Acids. 1994 Feb;7(1):27-43. doi: 10.1007/BF00808444. PMID:24185971 doi:http://dx.doi.org/10.1007/BF00808444

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Michal Harel, Alexander Berchansky

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