1y54

From Proteopedia

Revision as of 13:18, 20 March 2008 by OCA (Talk | contribs)
Jump to: navigation, search
Image:1y54.gif


PDB ID 1y54

Drag the structure with the mouse to rotate
, resolution 2.10Å
Ligands:
Activity: Beta-lactamase, with EC number 3.5.2.6
Coordinates: save as pdb, mmCIF, xml



Crystal structure of the native class C beta-lactamase from Enterobacter cloacae 908R complexed with BRL42715


Overview

BRL 42715, C6-(N1-methyl-1,2,3-triazolylmethylene)penem, is an active-site-directed inactivator of bacterial beta-lactamases. The crystal structure of Enterobacter cloacae 908R class C beta-lactamase in complex with BRL 42715, docking, and energy minimization studies explain stereoselectivity of the binding of C6-(heterocyclic methylene)penems against class C beta-lactamase.

About this Structure

1Y54 is a Single protein structure of sequence from Enterobacter cloacae. Full crystallographic information is available from OCA.

Reference

Crystal structure of BRL 42715, C6-(N1-methyl-1,2,3-triazolylmethylene)penem, in complex with Enterobacter cloacae 908R beta-lactamase: evidence for a stereoselective mechanism from docking studies., Michaux C, Charlier P, Frere JM, Wouters J, J Am Chem Soc. 2005 Mar 16;127(10):3262-3. PMID:15755127

Page seeded by OCA on Thu Mar 20 15:18:41 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1y54"
Personal tools