1ya3

From Proteopedia

proteopedia linkproteopedia link

spinqualitylabelsall models PDB ID 1ya3 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
, resolution 2.34Å
Ligands:
Gene:	NR3C2, MCR, MLR (Homo sapiens)
Coordinates:	save as pdb, mmCIF, xml

Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to progesterone and harboring the S810L mutation responsible for a severe form of hypertension

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

The S810L mutation within the human mineralocorticoid receptor (MR S810L) induces severe hypertension and switches progesterone from antagonist to agonist. Here we report the crystal structures of the ligand-binding domain of MR S810L in complex with progesterone and deoxycorticosterone, an agonist of both wild-type and mutant MRs. These structures, the first for MR, identify the specific contacts created by Leu810 and clarify the mechanism of activation of MR S810L.

Disease

Known diseases associated with this structure: Hypertension, early-onset, autosomal dominant, with exacerbation in pregnancy OMIM:[600983], Pseudohypoaldosteronism type I, autosomal dominant OMIM:[600983]

About this Structure

1YA3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension., Fagart J, Huyet J, Pinon GM, Rochel M, Mayer C, Rafestin-Oblin ME, Nat Struct Mol Biol. 2005 Jun;12(6):554-5. Epub 2005 May 22. PMID:15908963

Page seeded by OCA on Thu Mar 20 15:20:14 2008