1ytb

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Image:1ytb.jpg


PDB ID 1ytb

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, resolution 1.800Å
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF A YEAST TBP/TATA-BOX COMPLEX


Overview

The 2.5 A crystal structure of a TATA-box complex with yeast TBP shows that the eight base pairs of the TATA box bind to the concave surface of TBP by bending towards the major groove with unprecedented severity. This produces a wide open, underwound, shallow minor groove which forms a primarily hydrophobic interface with the entire under-surface of the TBP saddle. The severe bend and a positive writhe radically alter the trajectory of the flanking B-form DNA.

About this Structure

1YTB is a Single protein structure of sequence from Saccharomyces cerevisiae. The following page contains interesting information on the relation of 1YTB with [TATA-Binding Protein]. Full crystallographic information is available from OCA.

Reference

Crystal structure of a yeast TBP/TATA-box complex., Kim Y, Geiger JH, Hahn S, Sigler PB, Nature. 1993 Oct 7;365(6446):512-20. PMID:8413604

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