1zoq

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Image:1zoq.gif


PDB ID 1zoq

Drag the structure with the mouse to rotate
, resolution 2.37Å
Gene: IRF3 (Homo sapiens), CREBBP, CBP (Homo sapiens)
Activity: Histone acetyltransferase, with EC number 2.3.1.48
Coordinates: save as pdb, mmCIF, xml



IRF3-CBP complex


Contents

Overview

Interferon regulatory factor (IRF) 3 plays a critical role in triggering the activation of interferon antiviral genes. The structure of IRF-3 in association with the CBP/p300 coactivator by in this issue of Structure illuminates the mechanism of IRF activation and the structural flexibilities inherent in CBP/p300.

Disease

Known diseases associated with this structure: Blue-cone monochromacy OMIM:[303900], Colorblindness, protan OMIM:[303900], Rubenstein-Taybi syndrome OMIM:[600140]

About this Structure

1ZOQ is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

IRF-3 releases its inhibitions., Hiscott J, Lin R, Structure. 2005 Sep;13(9):1235-6. PMID:16154077

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