2bgd
From Proteopedia
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| , resolution 2.40Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | , , and | ||||||
| Activity: | Protein-tyrosine-phosphatase, with EC number 3.1.3.48 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE-BASED DESIGN OF PROTEIN TYROSINE PHOSPHATASE-1B INHIBITORS
Contents |
Overview
Using structure-based design, a new class of inhibitors of protein tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the 1,2,5-thiadiazolidin-3-one-1,1-dioxide template.
Disease
Known diseases associated with this structure: Abdominal body fat distribution, modifier of OMIM:[176885], Insulin resistance, susceptibility to OMIM:[176885]
About this Structure
2BGD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure-based design of protein tyrosine phosphatase-1B inhibitors., Black E, Breed J, Breeze AL, Embrey K, Garcia R, Gero TW, Godfrey L, Kenny PW, Morley AD, Minshull CA, Pannifer AD, Read J, Rees A, Russell DJ, Toader D, Tucker J, Bioorg Med Chem Lett. 2005 May 16;15(10):2503-7. PMID:15863305
Page seeded by OCA on Thu Mar 20 16:01:36 2008
Categories: Homo sapiens | Protein-tyrosine-phosphatase | Single protein | Black, E. | Breed, J. | Breeze, A L. | Embrey, K. | Garcia, R. | Gero, T W. | Godfrey, L. | Kenny, P W. | Minshull, C A. | Morley, A D. | Pannifer, A D. | Read, J. | Rees, A. | Russell, D J. | Toader, D. | Tucker, J. | CL | NA | PO4 | T1D | 1 | 1-dioxide template | 2 | 5-thiadiazolidin-3-one-1 | Hydrolase | Protein tyrosine phosphatase
