Structural highlights
4xx0 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , , |
| NonStd Res: | |
| Related: | 2fp4, 2fpi, 2fpg, 2fpp, 1euc, 1eud |
| Activity: | Succinate--CoA ligase (GDP-forming), with EC number 6.2.1.4 |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Function
[SUCA_PIG] Catalyzes the ATP- or GTP-dependent ligation of succinate and CoA to form succinyl-CoA. The nature of the beta subunit determines the nucleotide specificity (By similarity). [SUCB2_PIG] Catalyzes the GTP-dependent ligation of succinate and CoA to form succinyl-CoA (By similarity).
Publication Abstract from PubMed
Pig GTP-specific succinyl-CoA synthetase is an alphabeta-heterodimer. The crystal structure of the complex with the substrate CoA was determined at 2.1 A resolution. The structure shows CoA bound to the amino-terminal domain of the alpha-subunit, with the free thiol extending from the adenine portion into the site where the catalytic histidine residue resides.
Structure of GTP-specific succinyl-CoA synthetase in complex with CoA.,Huang J, Malhi M, Deneke J, Fraser ME Acta Crystallogr F Struct Biol Commun. 2015 Aug 1;71(Pt 8):1067-71. doi:, 10.1107/S2053230X15011188. Epub 2015 Jul 29. PMID:26249701[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Huang J, Malhi M, Deneke J, Fraser ME. Structure of GTP-specific succinyl-CoA synthetase in complex with CoA. Acta Crystallogr F Struct Biol Commun. 2015 Aug 1;71(Pt 8):1067-71. doi:, 10.1107/S2053230X15011188. Epub 2015 Jul 29. PMID:26249701 doi:http://dx.doi.org/10.1107/S2053230X15011188
