2bkt

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Image:2bkt.gif


PDB ID 2bkt

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, resolution 2.3Å
Sites:
Ligands:
Activity: Renin, with EC number 3.4.23.15
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF RENIN-PF00257567 COMPLEX


Contents

Overview

We have found that both enantiomeric configurations of the 6-alkoxymethyl-1-aryl-2-piperazinone scaffold display equipotent renin inhibition activity and similar SAR patterns. This enantiomeric flexibility is in contrast to a previously reported 3-alkoxymethyl-4-arylpiperidine scaffold.

Disease

Known diseases associated with this structure: Hyperproreninemia OMIM:[179820], Renal tubular dysgenesis OMIM:[179820]

About this Structure

2BKT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors., Powell NA, Clay EH, Holsworth DD, Bryant JW, Ryan MJ, Jalaie M, Zhang E, Edmunds JJ, Bioorg Med Chem Lett. 2005 May 2;15(9):2371-4. PMID:15837327

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