5x04

Structural highlights

Function

[FATB_UMBCA] Plays an essential role in chain termination during de novo fatty acid synthesis. High thioesterase activity for lauroyl-ACP versus other acyl-ACPs.^{[1] [2]}

References

1. ↑ Voelker TA, Worrell AC, Anderson L, Bleibaum J, Fan C, Hawkins DJ, Radke SE, Davies HM. Fatty acid biosynthesis redirected to medium chains in transgenic oilseed plants. Science. 1992 Jul 3;257(5066):72-4. PMID:1621095
2. ↑ Yuan L, Voelker TA, Hawkins DJ. Modification of the substrate specificity of an acyl-acyl carrier protein thioesterase by protein engineering. Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10639-43. PMID:7479856