Structural highlights
Function
[STKP_STRR6] Protein kinase involved in signal transduction pathways that regulate various cellular processes. Likely senses intracellular peptidoglycan subunits present in the cell division septa of actively growing cells; thus, intracellular unlinked peptidoglycan may serve as the signal molecules that trigger StkP phosphorylation activity on a set of substrates. Plays a crucial role in the regulation of cell shape and cell division of S.pneumoniae through control of at least DivIVA activity. Identified target substrates that are specifically phosphorylated by StkP in vivo, mainly on threonine residues, are DivIVA and StkP itself. Autophosphorylated StkP is a substrate for the cotranscribed protein phosphatase PhpP (shown in the avirulent strain Rx / Cp1015); PhpP and StkP appear to constitute a functional signaling couple in vivo.[1] [2]
References
- ↑ Fleurie A, Cluzel C, Guiral S, Freton C, Galisson F, Zanella-Cleon I, Di Guilmi AM, Grangeasse C. Mutational dissection of the S/T-kinase StkP reveals crucial roles in cell division of Streptococcus pneumoniae. Mol Microbiol. 2012 Feb;83(4):746-58. doi: 10.1111/j.1365-2958.2011.07962.x. Epub, 2012 Jan 11. PMID:22211696 doi:http://dx.doi.org/10.1111/j.1365-2958.2011.07962.x
- ↑ Beilharz K, Novakova L, Fadda D, Branny P, Massidda O, Veening JW. Control of cell division in Streptococcus pneumoniae by the conserved Ser/Thr protein kinase StkP. Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):E905-13. doi:, 10.1073/pnas.1119172109. Epub 2012 Mar 19. PMID:22431591 doi:http://dx.doi.org/10.1073/pnas.1119172109
