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2duv

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Revision as of 14:31, 20 March 2008 by OCA (Talk | contribs)
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Image:2duv.jpg


PDB ID 2duv

Drag the structure with the mouse to rotate
, resolution 2.2Å
Ligands:
Activity: Cyclin-dependent kinase, with EC number 2.7.11.22
Coordinates: save as pdb, mmCIF, xml



Structure of CDK2 with a 3-hydroxychromones


Overview

A novel series of 3-hydroxychromones were prepared and found to be CDK inhibitors. Isothiazolidine 1,1-dioxide analogues showed potent CDK1 and CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDAMB468 cancer cells.

About this Structure

2DUV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation., Lee J, Park T, Jeong S, Kim KH, Hong C, Bioorg Med Chem Lett. 2007 Mar 1;17(5):1284-7. Epub 2006 Dec 15. PMID:17178224

Page seeded by OCA on Thu Mar 20 16:31:54 2008

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