2r7e is a cool protein.
Structural highlights
2r7e is a 2 chain structure found in humans. It has 5 associated ligands ( , , BMA, MAN, NAG) and is coded for by 2 different genes, F8 and F8C. 2r7e has both and secondary structure. Alterations in this structure can lead to improper location of ligands, leading to failed protein function.
Ligands
2r7e has 5 ligands, which are binding sites for other proteins in Coagulation Factor VIII
Function
2r7e is a protein that makes up part of Coagulation Factor VIII, which is a protein complex involved in blood clotting in humans. Coagulation Factor VIII works with calcium and phosholipids to Factor X to its activated form Xa.
Disease
Mutations in 2r7e can alter the structure of Coagulation Factor VIII, leading to hemophilia a.
Relevance
Yay!
References
h http://www.uniprot.org/uniprot/P00451
