Sandbox Reserved 1334

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This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430.
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Myosin-11 is the heavy chain (or large polypeptide subunit) in myosin filaments, which are a key component in the actin-myosin interaction that enables muscles to contract.

PDB ID 5M05

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Contents

Function

5M05 is a heavy chain myosin protein involved in smooth muscle contractions. It acts as a major contractile protein, using ATP hydrolysis to convert chemical energy to mechanical energy and contract sarcomeres. The protein is homologous to myosin-11 in humans, as both conduct the same function.

Actin and Myosin filaments interact in a structure called a sarcomere to contract muscles.[1]
Actin and Myosin filaments interact in a structure called a sarcomere to contract muscles.[1]

Disease

Mutations in MYH11, the gene that codes for 5M05, have been identified in individuals with thoracic aortic aneurysms, and the familial version of the condition exhibits genetic and clinical heterogeneity. Additionally, mutations in this gene also appear to contribute to intestinal cancer, but this connection still warrants looking into.

Structural highlights

The of myosin-11 are responsible for binding to other proteins, crucial for the protein to interact with others as needed in smooth muscle contraction.

The and of myosin have an effect on how the protein can bind with actin,[2] which is integral to its role as a contractile protein, as myosin-11 contributes to the all-important myosin head.[3]


References

1. Rahgozar, S. "Intermediate Filaments."Slideshare. Retrieved February 26, 2018, from https://www.slideshare.net/mohammadmirmohammadi/11intermediate-filaments-cell-biology. 2. "5M05." Protein Data Bank in Europe. Retrieved February 26, 2018, from http://www.ebi.ac.uk/pdbe/entry/pdb/5m05. 3. Wampler, J.E. "The 20 Amino Acids and Their Role in Protein Structures." Protein Structures. Retrieved February 26, 2018, from https://proteinstructures.com/Structure/Structure/amino-acids.html.

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