2g6w
From Proteopedia
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| , resolution 2.14Å | |||||||
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| Ligands: | |||||||
| Activity: | 8-amino-7-oxononanoate synthase, with EC number 2.3.1.47 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Suicide inhibition of a-Oxamine Synthase: Structures of the Covalent Adducts of 8-Amino-7-oxonanoate Synthase with trifluoroalanine
Overview
The irreversible inhibition of 8-amino-7-oxononanoate synthase by trifluoroalanine involves decarboxylative defluorination of the inhibitor-PLP aldimine followed by attack of the conjugated imine by the amino group of the active site lysine to afford a covalently bound difluorinated intermediate which can subsequently undergo further HF losses and hydrolysis to afford a 2-(pyridoximine phosphate) acetoyl protein adduct.
About this Structure
2G6W is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Suicide inhibition of alpha-oxamine synthases: structures of the covalent adducts of 8-amino-7-oxononanoate synthase with trifluoroalanine., Alexeev D, Baxter RL, Campopiano DJ, Kerbarh O, Sawyer L, Tomczyk N, Watt R, Webster SP, Org Biomol Chem. 2006 Apr 7;4(7):1209-12. Epub 2006 Mar 1. PMID:16557306
Page seeded by OCA on Thu Mar 20 17:01:07 2008
