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2g9c

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Revision as of 15:02, 20 March 2008 by OCA (Talk | contribs)
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Image:2g9c.gif


PDB ID 2g9c

Drag the structure with the mouse to rotate
, resolution 1.70Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



Modified pyrimidines Specifically bind the purine riboswitch


Overview

The purine riboswitch is a genetic regulatory element found in the 5'-untranslated regions of Gram-positive bacteria that regulates expression of the mRNA specifically in response to either guanine or adenine. We report that the adenine-responsive RNA element is also capable of specifically recognizing pyrimidine compounds bearing modifications at the 6- or 5,6-positions in a fashion similar to that of purine compounds. Using isothermal titration calorimetry and X-ray crystallography, the binding of these compounds is characterized.

About this Structure

2G9C is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Modified pyrimidines specifically bind the purine riboswitch., Gilbert SD, Mediatore SJ, Batey RT, J Am Chem Soc. 2006 Nov 8;128(44):14214-5. PMID:17076468

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