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Contents

HRP1

Function

RNA Binding

The ribonucleotides of the recognized sequence 5'-AUAUAU-3' are designated from 5'-3' Ade2, Ade4, and Ade6; and Ura3, Ura5, and Ura7. The first two bases, Ade2 and Ura3, bind to the second RNA binding domain, and the remaining bases of the sequence bind to the first RNA binding domain. Each ribonucleotide has distinguishing interactions with the protein including


Adenines

SRp20 bound to RNA ligand and IgG binding domain 1 (PDB entry 2i2y)

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References


Hydrogen bond between Ade2 and Ura3
Hydrogen bond between Ade2 and Ura3

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Evie Nguyen

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