Cryptochrome

From Proteopedia

spinqualitylabelsall models Mouse cryptochrome-1 complex with FAD (PDB code 4i6g) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Cryptochrome (Cry) is a flavoprotein associated with the biological clock function. In Drosophila melanogaster it is also involved in blue-light photoreception[1]. Disease The absence of Cry resulting in the lack of functional clock system leads to elevated proinflammatory cytokine activation and thus to increase incidence of chronic diseases such as diabetes, obesity and also cancer[2].

3D Structures of cryptochrome

Updated on 20-November-2017

4i6e, 4k0r, 5t5x – mCry-1 – mouse
4jzy, 4gu5, 4k03 – Cry-1 + FAD – Drosophila melanogaster
1u3c – AtCry-1 PHR domain + FAD - Arabidopsis thaliana
1u3d – AtCry-1 PHR domain + FAD + AMPPNP
4ct0 – mCry-1 + PER2
4i6g – mCry-2 + FAD
4u8h – mCry-2 + PER2
4mlp – mCry-2 + carbazol derivative
3zxs – Cry-2 + FAD – Rhodobacter sphaeroides
2j4d, 2ijg – AtCry-3 + FAD
2vtb – AtCry-3 + FAD + DNA
3fy4 – AtCry 6-4 + FAD
1np7 – Cry - Synechocystis

References

1. ↑ Yoshii T, Todo T, Wulbeck C, Stanewsky R, Helfrich-Forster C. Cryptochrome is present in the compound eyes and a subset of Drosophila's clock neurons. J Comp Neurol. 2008 Jun 20;508(6):952-66. doi: 10.1002/cne.21702. PMID:18399544 doi:http://dx.doi.org/10.1002/cne.21702
2. ↑ Narasimamurthy R, Hatori M, Nayak SK, Liu F, Panda S, Verma IM. Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12662-7. doi:, 10.1073/pnas.1209965109. Epub 2012 Jul 9. PMID:22778400 doi:http://dx.doi.org/10.1073/pnas.1209965109