Sandbox GGC6
From Proteopedia
3BAJ
3BAJ is used in a lot of studies that have to do with allosteric activiation of human pancreatic alpha-amylase via chloride ions. It's primarily used as a anion substitution by using kinetic and structural experimentations. It's also composed of extracellular exosome which is a vesicle that is released by the extracellular region through fusion of limiting endosomal membranes of multivesicular bodies within the plasma membrane. [1] or to the article describing Jmol [2].
FunctionIts biochemical function is an Alpha-amylase activator that allows for the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units. It also has a biological process of polysaccharide digestion which is a biochemical, chemical, and physical process that is carried out by living organisms to break down ingested polysaccharides into components that can be easily directed and absorbed into metabolism. DiseaseNo diseases have been found to be associated with this. It's primarily used in experiments but it is found in homo sapiens RelevanceThis is one type of major molecule that is used as an alternative anion which can induce some level of enzymatic activity despite very different atomic geometries, sizes, and polyatomic natures. The largest anion in this group ,nitrate, can comfortably fit in the chloride binding pocket making all necessary hydrogen bonds when using it as a modified enzyme. Secondary structure of the 3BAJ shows the alpha and beta helix sheets</scene> This is a view of the only found in 3BAJ The ligand shown is composed of NO3 The other ligands are NAG (N-acetyl-D-glucosamine), ARE (acarbose derived pentasaccharide), and a calcium ion
References
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