Structural highlights
Function
[CEP85_HUMAN] Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856).[1]
References
- ↑ Chen C, Tian F, Lu L, Wang Y, Xiao Z, Yu C, Yu X. Characterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction. J Cell Sci. 2015 Sep 1;128(17):3290-303. doi: 10.1242/jcs.171637. Epub 2015 Jul, 28. PMID:26220856 doi:http://dx.doi.org/10.1242/jcs.171637