Structural highlights
Function
[DAN_DROME] Probable transcription factor with a role in the retinal determination (RD) network. Regulates ato expression and is required for normal R8 induction and differentiation. Danr appears to repress Dan expression, but Dan is required for Danr expression anterior to the morphogenetic furrow (MF). Dan and Danr lie downstream of so and require dac function for highest levels of expression. Contributes to differentiation of antenna-specific characteristics; effector gene that acts downstream of homothorax (hth), Distal-less (Dll), cut (ct) and spineless (ss) genes to control differentiation of distal antennal structures.[1] [2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Emerald BS, Curtiss J, Mlodzik M, Cohen SM. Distal antenna and distal antenna related encode nuclear proteins containing pipsqueak motifs involved in antenna development in Drosophila. Development. 2003 Mar;130(6):1171-80. PMID:12571108
- ↑ Curtiss J, Burnett M, Mlodzik M. distal antenna and distal antenna-related function in the retinal determination network during eye development in Drosophila. Dev Biol. 2007 Jun 15;306(2):685-702. Epub 2007 Apr 12. PMID:17493605 doi:http://dx.doi.org/S0012-1606(07)00765-8
