2kv3

Structural highlights

Function

[REG4_HUMAN] Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Kamarainen M, Heiskala K, Knuutila S, Heiskala M, Winqvist O, Andersson LC. RELP, a novel human REG-like protein with up-regulated expression in inflammatory and metaplastic gastrointestinal mucosa. Am J Pathol. 2003 Jul;163(1):11-20. PMID:12819006 doi:http://dx.doi.org/10.1016/S0002-9440(10)63625-5
2. ↑ Ho MR, Lou YC, Wei SY, Luo SC, Lin WC, Lyu PC, Chen C. Human RegIV protein adopts a typical C-type lectin fold but binds mannan with two calcium-independent sites. J Mol Biol. 2010 Oct 1;402(4):682-95. Epub 2010 Aug 6. PMID:20692269 doi:http://dx.doi.org/10.1016/j.jmb.2010.07.061