2lw4

Structural highlights

Function

[TCEA2_HUMAN] Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.^[1]

References

1. ↑ Sijbrandi R, Fiedler U, Timmers HT. RNA polymerase II complexes in the very early phase of transcription are not susceptible to TFIIS-induced exonucleolytic cleavage. Nucleic Acids Res. 2002 Jun 1;30(11):2290-8. PMID:12034815