2mum

Structural highlights

Function

[YNG2_YEAST] Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis.^{[1] [2] [3] [4]}

References

1. ↑ Loewith R, Meijer M, Lees-Miller SP, Riabowol K, Young D. Three yeast proteins related to the human candidate tumor suppressor p33(ING1) are associated with histone acetyltransferase activities. Mol Cell Biol. 2000 Jun;20(11):3807-16. PMID:10805724
2. ↑ Choy JS, Tobe BT, Huh JH, Kron SJ. Yng2p-dependent NuA4 histone H4 acetylation activity is required for mitotic and meiotic progression. J Biol Chem. 2001 Nov 23;276(47):43653-62. Epub 2001 Sep 5. PMID:11544250 doi:http://dx.doi.org/10.1074/jbc.M102531200
3. ↑ Nourani A, Doyon Y, Utley RT, Allard S, Lane WS, Cote J. Role of an ING1 growth regulator in transcriptional activation and targeted histone acetylation by the NuA4 complex. Mol Cell Biol. 2001 Nov;21(22):7629-40. PMID:11604499 doi:http://dx.doi.org/10.1128/MCB.21.22.7629-7640.2001
4. ↑ Choy JS, Kron SJ. NuA4 subunit Yng2 function in intra-S-phase DNA damage response. Mol Cell Biol. 2002 Dec;22(23):8215-25. PMID:12417725