Structural highlights
Function
[PICK1_HUMAN] Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ASIC1/ASIC3 channel.[1]
References
- ↑ Shao X, Zhu L, Wang Y, Lu Y, Wang W, Zhu J, Shen Y, Xia J, Luo J. Threonine 82 at the PDZ domain of PICK1 is critical for AMPA receptor interaction and localization. Neurochem Int. 2010 Jul;56(8):962-70. doi: 10.1016/j.neuint.2010.04.006. Epub, 2010 Apr 18. PMID:20403402 doi:http://dx.doi.org/10.1016/j.neuint.2010.04.006
