Structural highlights
2y3y is a 5 chain structure with sequence from Helpg and Miscellaneous nucleic acid. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , |
| Related: | 2caj, 2wvb, 2wvd, 2ca9, 2wve, 2wvf, 2wvc, 2cad |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[NIKR_HELPG] Transcriptional regulator.[HAMAP-Rule:MF_00476]
Publication Abstract from PubMed
The crystal structure of Helicobacter pylori holo-NikR, a Ni(2+)-dependent transcription factor, determined at pH 7.3, shows four square-planar nickel-binding sites, involving one cysteinate and three histidine ligands. This observation reconciles previous inconsistencies among calorimetric data, structural information at non-physiological pH, and computational studies.
Holo-Ni(2+)Helicobacter pylori NikR contains four square-planar nickel-binding sites at physiological pH.,Benini S, Cianci M, Ciurli S Dalton Trans. 2011 Aug 21;40(31):7831-3. Epub 2011 Jul 4. PMID:21725560[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Benini S, Cianci M, Ciurli S. Holo-Ni(2+)Helicobacter pylori NikR contains four square-planar nickel-binding sites at physiological pH. Dalton Trans. 2011 Aug 21;40(31):7831-3. Epub 2011 Jul 4. PMID:21725560 doi:10.1039/c1dt11107h
