This is a default text for your page Colony-stimulating factor. Click above on edit this page to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
Function
Colony-stimulating factors (CSF) are growth regulatory factors which influence functional activity, survival, proliferation and differentiation of myeloid mature and haemopoietic cells. Four distinct CSFs were characterized[3].
- Granulocyte colony-stimulating factor (G-CSF) act on proliferation, functional stimulation and differentiation of progenitors of neutrophils.
- Granulocyte-macrophage colony-stimulating factor (GM-CSF) act on proliferation, functional stimulation and differentiation of progenitors of neutrophils, monocytes and granulocytes[4].
- Macrophage colony-stimulating factor (M-CSF) act on proliferation, functional stimulation and differentiation of progenitors of monocytes and macrophages.
- multi-colony-stimulating factor also known as interleukin 3.
Disease
Relevance
Depletion of CSFs have therapeutic benefit in many inflammatory and autoimmune conditions[5]. G-CSF and GM-CSF are used to increase low white blood cell levels in cancer patients following chemotherapy and to release haematopoietic stem cells which replace bone marrow cells after anti-cancer treatments[6]. G-CSF is a neurotrophic factor and thus a candidate for the treatment of neurodegenerative conditions[7]. G-CSF and GN-CSF ar commercially available for clinical use[8].
Structural highlights