Structural highlights
Function
[MARF1_MOUSE] Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks.[1] [2]
References
- ↑ Su YQ, Sugiura K, Sun F, Pendola JK, Cox GA, Handel MA, Schimenti JC, Eppig JJ. MARF1 regulates essential oogenic processes in mice. Science. 2012 Mar 23;335(6075):1496-9. doi: 10.1126/science.1214680. PMID:22442484 doi:http://dx.doi.org/10.1126/science.1214680
- ↑ Su YQ, Sun F, Handel MA, Schimenti JC, Eppig JJ. Meiosis arrest female 1 (MARF1) has nuage-like function in mammalian oocytes. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18653-60. doi:, 10.1073/pnas.1216904109. Epub 2012 Oct 22. PMID:23090997 doi:http://dx.doi.org/10.1073/pnas.1216904109
