Function
Oxysterol-binding protein homolog (Osh) mediate sterol transport from the ER to mitochondria. Sterols are synthesized in the ER and are present in membranes and affect the membrane fluidity and permeability[1]. Osh4 or Kes1 is involved in membrane and lipid trafficking through trans-Golgi network and endosomal systems[2].
Structural highlights
The structure of the complex between Osh4 and cholesterol shows the covered by a lid formed by the protein N-terminal with the ligand forming numerous interactions with Osh4[3].