Synaptotagmin

From Proteopedia

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spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function Synaptotagmin-1 (SYT1) is a synaptic vesicle membrane protein and is a sensor which induces release in neurons upon binding of Ca+2 ions[1]. The C2A domain of SYT binds phospholipids in Ca+2-dpendent manner[2]. Disease Relevance Structural highlights At the tip of SYT C2A domain there are three tightly clustered Ca+2 binding sites formed by 5 aspartates and one serine.

3D structures of synaptotagmin

Updated on 03-December-2018

References

1. ↑ Xu J, Pang ZP, Shin OH, Sudhof TC. Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release. Nat Neurosci. 2009 Jun;12(6):759-66. doi: 10.1038/nn.2320. PMID:19412166 doi:http://dx.doi.org/10.1038/nn.2320
2. ↑ Zhang X, Rizo J, Sudhof TC. Mechanism of phospholipid binding by the C2A-domain of synaptotagmin I. Biochemistry. 1998 Sep 8;37(36):12395-403. doi: 10.1021/bi9807512. PMID:9730811 doi:http://dx.doi.org/10.1021/bi9807512